white whale
noun
1
2
or less commonly great white whale
: something (such as a goal or object) that is obsessively pursued
It was the old man's white whale, the holy grail shining at the end of the dream, on and off the rails, as he chased scripts, directors, and movie stars of the proper magnitude.—Rich Cohen
For drug makers, developing the first Alzheimer's therapy has long been seen as the great white whale: the toughest challenge and biggest opportunity.—Robert Weisman
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Merriam-Webster unabridged
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